How strong is the evidence for the use of perioperative β blockers in non-cardiac surgery? Systematic review and meta-analysis of randomised controlled trials

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Irritable bowel syndrome with diarrhoea (IBS-D) (n=513). Primary outcome: Gastrointestinal and wider health burden of IBS-D, including medications used for symptom relief and perceived care shortfalls.

Q: What does this research mean for the field?

Irritable bowel syndrome with diarrhoea (IBS-D) imposes a substantial health burden, characterized by high rates of psychiatric comorbidities, significant dissatisfaction with current treatments, and a perceived lack of support from healthcare professionals. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

P.J. Devereaux; W. Scott Beattie; P. Choi; Neal H. Badner; Gordon Guyatt; Juan Carlos Villar; Claudio S. Cinà; Kate Leslie; Michael J. Jacka; Víctor M. Montori; Mohit Bhandari; Álvaro Avezum; Alexandre Biasi Cavalcanti; Julian W Giles; Thomas Schricker; Homer Yang; Carl-Johan Jakobsen; Salim Yusuf

doi:10.1136/bmj.38503.623646.8f

Study Design

Type

Cross-Sectional (n=513)

Multicenter

Yes

Structured PICO

P

Population

513 eligible patients with irritable bowel syndrome with diarrhoea (IBS-D) (age 18-65 years, diagnosed by a doctor, symptoms present within the past 12 months, currently using prescription or OTC medicines), mean age 40.9, 70% female, multinational (France, Germany, Italy, Spain, UK, Canada, Australia).

O

Outcome

Gastrointestinal and wider health burden of IBS-D, including medications used for symptom relief and perceived care shortfallspatient reported

Implication

IBS-D imposes a substantial burden on patients' quality of life, highlighting significant dissatisfaction with current treatments and a need for better supportive care.

Abstract

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Discussion

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Cite This Study

Devereaux et al. (2005) conducted a cross-sectional in Irritable bowel syndrome with diarrhoea (IBS-D) (n=513).

synapsesocial.com/papers/6a08b0de113ba5b476de66c4 https://doi.org/10.1136/bmj.38503.623646.8f

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How strong is the evidence for the use of perioperative β blockers in non-cardiac surgery? Systematic review and meta-analysis of randomised controlled trials

Study Design

Structured PICO

Implication

Abstract

Discussion

Cite This Study

How strong is the evidence for the use of perioperative β blockers in non-cardiac surgery? Systematic review and meta-analysis of randomised controlled trials

Study Design

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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