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Motoric cognitive risk (MCR) syndrome is a pre-dementia syndrome linked to increased risk of dementia and mortality. The relationship between integrated metabolic-anthropometric indices and MCR, particularly potential nonlinear associations, remains underexplored in Chinese populations. This cross-sectional study aimed to investigate the associations between novel metabolic-anthropometric indices – including lipid accumulation product, conicity index (CI), body roundness index (BRI), and cardiometabolic index – and MCR in Chinese middle-aged and older adults, and to identify critical thresholds of association. We analyzed data from 5790 participants aged ≥45 years from the China Health and Retirement Longitudinal Study 2015 wave. MCR was defined as coexisting slow gait and subjective cognitive complaints in individuals without dementia or mobility disability. Multivariable logistic regression assessed associations, and threshold effect models explored nonlinear relationships. Among the participants, 156 (2.7%) were identified with MCR. After full adjustment for demographic and lifestyle factors, lipid accumulation product (odds ratio OR = 1.005, 95% confidence intervals CIs = 1.002–1.009), CI (OR = 1.431, 95% CI = 1.102–1.859), BRI (OR = 1.041, 95% CI = 1.016–1.067), and cardiometabolic index (OR = 1.280, 95% CI = 1.052–1.558) were independently associated with MCR. Notably, threshold analysis revealed a critical inflection point for CI at 6.489. Below this value, no significant association was observed, whereas above it, the association with MCR was significantly stronger (OR = 2.146, 95% CI = 1.553–2.966). For BRI, risk increased significantly below a threshold of 7.083. Subgroup analyses showed consistently stronger associations in females, adults aged ≥60, and those with no formal education. Specific metabolic-anthropometric indices, particularly CI with a sharp risk threshold at 6.489, are robustly associated with MCR in Chinese older adults. These indices may serve as valuable screening tools, and the identified thresholds offer potential targets for risk stratification and early intervention, especially in high-risk subgroups.
Deng et al. (Fri,) studied this question.