A Peripheral Blood Transcriptome Biomarker Test to Diagnose Functional Recovery Potential in Advanced Heart Failure

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  Figure 1.. Functional recovery potential is an novel integrated clinical parameter, defined as a clinical composite parameter that includes chronological age as well as personal biological age, measurable by established and validated heart failure, secondary organ dysfunction, co-morbidities, frailty and disability instruments. Functional recovery potential (FRP) represents the instantaneous potential of the person with advanced heart failure (AdHF) to cope with stressors such as AdHF surgical/interventional therapies and is a surrogate parameter for a long-term survival benefit. Heart failure severity tools include HFSS, Seattle Heart Failure Model and University of California Los Angeles scores. Organ dysfunction severity tools include Sequential Organ Failure Assessment and Model of Endstage Liver Disease Except INR scores. Co-morbidity burden tools include Society of Thoracic Surgeons and EuroSCORE. Frailty tools include the FRIED scale. Disabilities can be measured by the Activities-of-Daily-Living scale. A high FRP is defined as the composite score improving after AdHF interventions. A low FRP is defined as the composite score not improving after AdHF interventions. Our central…