Key result
Persistent atrial fibrillation in goats was associated with more perpendicular orientation of epicardial to endocardial bundles compared to acute AF (7.63% vs 21.25% for angles <20°; P<0.01).
Why the study?
Does persistent AF alter atrial bundle architecture and anisotropy of conduction compared to acute AF in a goat model?
Population
Goats with acute AF (n=6) or persistent AF (n=5)
Comparison
Persistent AF vs Acute AF
Design
Preclinical
Authors
Loading...
Supports endo-epicardial dissociation in persistent AF substrate; leaves open human translation and therapeutic relevance.
Does persistent AF alter atrial bundle architecture and anisotropy of conduction compared to acute AF in a goat model?
Absolute Event Rate: 7.63% vs 21.25%
p-value: p=<0.01
Persistent atrial fibrillation leads to structural rearrangement of atrial bundles, resulting in endo-epicardial dissociation of electrical activity and the development of a 3-dimensional AF substrate.
Maesen et al. (2013) studied Atrial fibrillation (n=11). Persistent AF vs. Acute AF was evaluated on Percentage of angles <20° between epicardial and endocardial bundle directions (p=<0.01). Persistent atrial fibrillation in goats was associated with more perpendicular orientation of epicardial to endocardial bundles compared to acute AF (7.63% vs 21.25% for angles <20°; P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: