Key result
RAAS drives all stages of the cardiovascular continuum from risk factor clustering to heart failure.
Why the study?
The renin-angiotensin-aldosterone system plays a key role across all stages of the cardiovascular continuum, warranting an analysis of how its components drive underlying pathophysiology and potential arrest of progression.
This review highlights the pathophysiological role of the renin-angiotensin-aldosterone system across all stages of the cardiovascular continuum, from risk factors to heart failure.
Supports RAAS inhibition in CV care; confirms role across continuum but leaves open optimal strategies.
The cardiovascular continuum describes how several cardiovascular risk factors contribute to the development of atherothrombosis, ischemic heart disease, and peripheral arteriopathy, leading to cardiac and renal failure and ultimately death. Due to its multiple valences, the renin-angiotensin-aldosterone system plays an important role in all stages of the cardiovascular continuum, starting from a cluster of cardiovascular risk factors, and continuing with the development of atherosclerosis thorough various mechanisms, and culminating with heart failure. Therefore, this article aims to analyze how certain components of the renin-angiotensin-aldosterone system (converting enzymes, angiotensin, angiotensin receptors, and aldosterone) are involved in the underlying pathophysiology of the cardiovascular continuum and the possible arrest of its progression.
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Pop et al. (2024) conducted a review in Cardiovascular continuum. Renin-angiotensin-aldosterone system components was evaluated. The renin-angiotensin-aldosterone system plays a crucial role in all stages of the cardiovascular continuum, from risk factor clustering to atherosclerosis and heart failure.
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