Key result
Traditional medicine C-C,N,S inhibits atrial remodeling in AF by targeting inflammatory signaling pathways.
Why the study?
The core pathological process and mechanism of the herbal combination C-C,N,S in treating atrial fibrillation remain unclear.
Does the C-C,N,S herbal combination modulate inflammatory pathways to treat atrial fibrillation in network pharmacology and gene expression models?
Does the C-C,N,S herbal combination modulate inflammatory pathways to treat atrial fibrillation in network pharmacology and gene expression models?
Network pharmacology and gene set enrichment analysis suggest that the traditional Chinese medicine combination C-C,N,S may treat atrial fibrillation by modulating inflammatory pathways including TNF, IL-17, and PI3K-Akt.
Triangle drug combination of Citrus medica L.var.sarcodactylis Swingle , Naradostachys jatamansi DC. and Salvia miltiorrhiza Bge. (C-C,N,S) is usually appeared in atrial fibrillation-treating (AF) decoction and has good clinical effects. However, the core pathological process and mechanism of C-C,N,S intervening AF is unclear. So we intend to use network pharmacology and gene set enrichment analysis to explore the potential mechanism. We detected all compounds of C-C,N,S from CNKI database, predicted its bioactive compounds and potential anti-AF targets from related online platforms and databases. Then through PPI network, gene expression analyses, GO and KEGG pathway enrichment analysis on anti-AF targets, we determined the potential mechanism of C-C,N,S treating AF. Finally we used gene set enrichment analysis (GSEA) to validate the therapeutic effect of C-C,N,S. In conclusion, the therapeutic effect of C-C,N,S treating AF was focused on anti-inflammation. C-C,N,S can regulate inflammatory process and inhibit atrial remodeling and fibrosis through regulating TNF signaling pathway, IL-17 signaling pathway (MAPK signaling involved in) and PI3K-Akt signaling pathway. Some genes regulated by specific herbal medicine explained reason of the combination.
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Yang et al. (2023) studied Atrial fibrillation (n=30). C-C,N,S (Citrus medica L.var.sarcodactylis Swingle, Naradostachys jatamansi DC. and Salvia miltiorrhiza Bge.) was evaluated on Signaling pathways and gene targets associated with C-C,N,S treatment of atrial fibrillation. Network pharmacology and gene set enrichment analysis revealed that the traditional Chinese medicine combination C-C,N,S treats atrial fibrillation by regulating inflammatory processes and inhibiting atrial remodeling through the TNF, IL-17, and PI3K-Akt signaling pathways.
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