Key result
Natural product extracts show potential antiarrhythmic effects in AF by modulating ion channels and connexins.
Why the study?
Adverse effects and high recurrence rates after antiarrhythmic drug withdrawal affect compliance and prognosis in atrial fibrillation, creating an urgent need for safer and more effective drugs.
Do active components extracted from natural products improve atrial fibrillation by regulating ion channels?
Do active components extracted from natural products improve atrial fibrillation by regulating ion channels?
Active components from natural products represent potential alternatives or adjuncts for antiarrhythmic therapy in atrial fibrillation, pending definitive clinical trial evidence.
Antiarrhythmic drugs (AADs) have a therapeutic effect on atrial fibrillation (AF) by regulating the function of ion channels. However, several adverse effects and high recurrence rates after drug withdrawal seriously affect patients' medication compliance and clinical prognosis. Thus, safer and more effective drugs are urgently needed. Active components extracted from natural products are potential choices for AF therapy. Natural products like Panax notoginseng (Burk.) F.H. Chen, Sophora flavescens Ait., Stephania tetrandra S. Moore., Pueraria lobata (Willd.) Ohwi var. thomsonii (Benth.) Vaniot der Maesen., and Coptis chinensis Franch. have a long history in the treatment of arrhythmia, myocardial infarction, stroke, and heart failure in China. Based on the classification of chemical structures, this article discussed the natural product components' therapeutic effects on atrial fibrillation by regulating ion channels, connexins, and expression of related genes, in order to provide a reference for development of therapeutic drugs for atrial fibrillation.
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He et al. (2022) conducted a review in Atrial fibrillation. Natural products and active components was evaluated. Active components extracted from natural products demonstrate potential therapeutic effects on atrial fibrillation by regulating ion channels, connexins, and related gene expression.
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