Why the study?
Arrhythmia carries high morbidity and mortality, and summarizing the Ca2+-regulatory mechanisms of natural drugs and their active ingredients provides ideas for developing innovative antiarrhythmic therapies.
Natural drugs and their active ingredients offer potential antiarrhythmic efficacy through the regulation of calcium channels, providing ideas for innovative drug development.
Natural compounds may identify calcium channel targets for arrhythmias; leaves open validation in prospective trials before any clinical adoption.
Arrhythmia is characterized by abnormal heartbeat rhythms and frequencies caused by heart pacing and conduction dysfunction. Arrhythmia is the leading cause of death in patients with cardiovascular disease, with high morbidity and mortality rates, posing a serious risk to human health. Natural drugs and their active ingredients, such as matrine(MAT), tetrandrine(TET), dehydroevodiamine, tanshinone IIA, and ginsenosides, have been widely used for the treatment of atrial fibrillation, ventricular ectopic beats, sick sinus syndrome, and other arrhythmia-like diseases owing to their unique advantages. This review summarizes the mechanism of action of natural drugs and their active ingredients in the treatment of arrhythmia via the regulation of Ca2+, such as alkaloids, quinones, saponins, terpenoids, flavonoids, polyphenols, and lignan compounds, to provide ideas for the innovative development of natural drugs with potential antiarrhythmic efficacy.
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Zhang et al. (2023) studied this question.
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