Key result
Whole-body cardiac EP models require physiological replication, pathophysiological interventions, and signal measurement.
Why the study?
Developing effective cardiac electrophysiology experimental models across scales requires addressing key challenges in replicating human physiology, capturing pathophysiology, and meeting measurement demands.
This review provides a systematic engineering framework for designing whole-body cardiac electrophysiology experimental models, emphasizing physiological replication, pathophysiological manipulation, and measurement fidelity.
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Framework may guide whole-body cardiac model design; leaves open validation before clinical translation.
Zenger et al. (2023) conducted a review in Cardiac electrophysiology and acute ischemia. Engineering approach to experimental models was evaluated. An engineering approach to developing whole-body experimental models of cardiac electrophysiology requires addressing physiological replication, pathophysiological interventions, and signal measurement.
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