Key result
The ACE gene DD genotype was significantly more frequent in IgA nephropathy patients with declining renal function (43%) versus stable function (16%), and predicted proteinuria reduction with ACE inhibitors.
Why the study?
Does ACE gene deletion polymorphism predict the progression of IgA nephropathy and therapeutic responsiveness to ACE inhibitors?
Population
53 patients with biopsy-proven IgA nephropathy monitored over 5 years, and 46 age-matched controls without…
Comparison
ACE inhibitor treatment for 48 weeks. vs Patients with ID or II genotypes, and healthy…
Design
Cohort
Follow-up
5 years for monitoring, 48 weeks for ACE inhibitor treatment
Authors
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May support risk stratification in IgA nephropathy; leaves open whether genotyping should guide ACE inhibitor use.
Observational (n=99)
Does ACE gene deletion polymorphism predict the progression of IgA nephropathy and therapeutic responsiveness to ACE inhibitors?
Absolute Event Rate: 43% vs 16%
The ACE gene DD genotype is a risk factor for progression to chronic renal failure in IgA nephropathy and predicts a favorable antiproteinuric response to ACE inhibitors.
Yoshida et al. (1995) conducted an observational in IgA nephropathy (n=99). ACE inhibitor vs. Stable renal function / ID or II genotypes / Controls was evaluated on Frequency of DD genotype in patients with declining renal function. The ACE gene DD genotype was significantly more frequent in IgA nephropathy patients with declining renal function (43%) versus stable function (16%), and predicted proteinuria reduction with ACE inhibitors.
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