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August 26, 2011Journal of the Turkish-German Gynecological AssociationOpen Access

Diagnosis and treatment of deep-vein thrombosis and approach to venous thromboembolism in obstetrics and gynecology

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Key result

Normal pregnancy increases the incidence of venous thromboembolism six-fold compared to the general female population, with low-molecular-weight heparin serving as the treatment of choice.

Population

Patients with suspected or confirmed deep vein thrombosis, including pregnant women in the antenatal and…

Design

Review

Authors

KBKamil Mehmet BurgazliUniversitätsklinikum Gießen und MarburgMBMehmet BilginAdnan Menderes UniversityEKEthem KavukçuAkdeniz University

Discussion

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Implication

Prompts routine VTE vigilance in pregnancy care; leaves open need for prospective trials on risk stratification.

Structured PICO

P
Population
Patients with suspected or confirmed deep vein thrombosis, including pregnant women in the antenatal and postpartum periods
I
Intervention
Diagnostic algorithms (pre-test probability, D-Dimer testing, compression ultrasound) and treatments (low-molecular-weight heparin, anticoagulation therapy, inferior vena cava filters)

This review outlines the diagnostic algorithm for suspected lower-extremity thrombosis and highlights low-molecular-weight heparin as the preferred treatment for DVT, particularly during pregnancy.

Limitations

  • Lack of consensus on the appropriate dose of low-molecular-weight heparin during pregnancy and whether anti-Xa levels need to be monitored
  • More research is required to optimally define factors that predict an increased risk of recurrent DVT

Cite This Study

Burgazli et al. (2011) conducted a review in Deep vein thrombosis and venous thromboembolism. Low-molecular-weight heparin was evaluated. Normal pregnancy increases the incidence of venous thromboembolism six-fold compared to the general female population, with low-molecular-weight heparin serving as the treatment of choice.

synapsesocial.com/papers/6a08c8ee865c3eaa9b01ea06https://doi.org/10.5152/jtgga.2011.39
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low molecular weight heparin in pregnancy: current issues2005 · 94 citations
  2. 2Long-term outcomes after deep venous thrombosis of the lower extremities1998 · 69 citations
  3. 3Thrombophilia testing in people with venous thromboembolism: systematic review and cost-effectiveness analysis2009 · 34 citations
  4. 4Trends in the Incidence of Deep Vein Thrombosis and Pulmonary Embolism1998 · 2,678 citations
  5. 5Acenocoumarol and Heparin Compared with Acenocoumarol Alone in the Initial Treatment of Proximal-Vein Thrombosis1992 · 480 citations