Key result
Hospital mortality was not significantly different between Hancock xenograft and Starr-Edwards valves for aortic (6.4% vs 6.9%), mitral (8.6% vs 9.7%), or double valve replacement (10.2% vs 7.5%).
Why the study?
Does the Hancock porcine xenograft valve improve mortality and morbidity compared to the Starr-Edwards caged-ball valve in patients undergoing valve replacement?
Cohort (n=1,748)
Does the Hancock porcine xenograft valve improve mortality and morbidity compared to the Starr-Edwards caged-ball valve in patients undergoing valve replacement?
The Hancock porcine xenograft valve demonstrated comparable hospital mortality to the Starr-Edwards caged-ball valve across aortic, mitral, and double-valve replacements.
Authors
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Similar hospital mortality supports individualized valve selection; leaves open long-term morbidity differences in non-randomized data.
Oyer et al. (1977) conducted a cohort in Valvular heart disease requiring valve replacement (n=1,748). Hancock glutaraldehyde-fixed porcine xenograft vs. Starr-Edwards caged-ball valve was evaluated on Hospital mortality. Hospital mortality was not significantly different between Hancock xenograft and Starr-Edwards valves for aortic (6.4% vs 6.9%), mitral (8.6% vs 9.7%), or double valve replacement (10.2% vs 7.5%).
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