Key result
Successful AF cardioversion linked to ~7% 30-day risk of decompensated HF, driven by prior HF hospitalization.
Why the study?
The incidence of and risk factors for heart failure after successful electrical and ablative cardioversion of atrial fibrillation and atrial flutter needed to be determined.
Cohort (n=451)
No
Effect estimate: OR 3.91 (95% CI 1.82-8.39)
Decompensated heart failure occurs in approximately 7.3% of patients following successful cardioversion for atrial fibrillation or flutter despite maintenance of sinus rhythm, particularly in those with prior HF, higher BMI, or valve disease.
May support closer post-cardioversion HF monitoring in patients with prior hospitalization; hypothesis-generating for prevention trials.
To determine the incidence of and risk factors for HF after successful electrical and ablative cardioversion (CV) of atrial fibrillation (AF) and atrial flutter (AFL). Retrospective cohort study. Single center academic institution. Seven hundred fifty-five patients underwent successful elective CV from July 1, 2018 to May 20, 2019. Patients presenting in arrhythmias other than AF or AFL, those who developed HF due to alternative etiologies, and those who developed arrhythmia recurrence within 30 days were excluded. Medical records of the remaining 451 patients were reviewed before and after CV. Development of heart failure despite sinus rhythm following CV and the risk factors associated with this outcome. Thirty-three (7.3 %) of 451 patients who met inclusion criteria for our study developed new or worsening HF symptoms while maintaining sinus rhythm (SR) after successful CV. Symptoms were reported an average of 5.1 days following CV (range 0–17 days, SD 4.71). Following a multivariate stepwise logistic regression model, prior HF hospitalization (OR 3.91, 95 % CI 1.82–8.39), BMI (OR 1.06, 95 % CI 1.02–1.11), and valve disease (OR 2.51, 95 % CI 1.12–5.60) remained significant risk factors, and anti-arrhythmic drug (AAD) use was marginally significant (OR 2.02, 95 % CI 0.95–4.31). Despite maintenance of SR, 7.3 % of patients developed decompensated HF in the 30 days following successful CV of AF or AFL, indicating this complication may be more frequent than previously believed. Predictors of HF post-CV included elevated BMI, valve disease, previous HF hospitalization, and prior AAD use.
No takes yet. Share an insight, caveat, or question.
Healy et al. (2024) conducted a cohort in Atrial fibrillation and atrial flutter (n=451). Successful electrical and ablative cardioversion was evaluated on Development of new or worsening heart failure symptoms while maintaining sinus rhythm (OR 3.91, 95% CI 1.82-8.39). Successful cardioversion for atrial fibrillation or flutter was followed by decompensated heart failure in 7.3% of patients within 30 days, with prior HF hospitalization as a key risk factor (OR 3.91).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: