Key result
Asymptomatic sarcoidosis is linked to ~20% lower left atrial active emptying fraction versus healthy controls.
Why the study?
Cardiac involvement causes significant morbidity and death in sarcoidosis, but many patients remain asymptomatic until late stages.
Does 3D echocardiography detect subclinical left atrial dysfunction in asymptomatic patients with sarcoidosis compared to healthy volunteers?
Cross-Sectional (n=84)
Does 3D echocardiography detect subclinical left atrial dysfunction in asymptomatic patients with sarcoidosis compared to healthy volunteers?
3D echocardiography can detect subclinical left atrial dysfunction, specifically reduced active and total emptying fractions, in asymptomatic patients with sarcoidosis.
Answers are grounded in this paper and cite their sources.
3D echo may detect subclinical LA dysfunction in asymptomatic sarcoidosis; hypothesis-generating for prognostic validation.
BACKGROUND: Cardiac involvement is the leading cause of morbidity and death in patients with sarcoidosis. However, many patients remain asymptomatic until the late-stage. In this study, we investigated the left atrial (LA) phasic volumes and functions changes by three-dimensional (3D) echocardiography measurements in asymptomatic patients with sarcoidosis, which has good correlation with cardiac magnetic resonance imaging. METHODS: In this cross-sectional study, 44 asymptomatic patients with sarcoidosis and 40 age, sex and BMI-matched healthy volunteers underwent two-dimensional (2D) and 3D-echocardiograpy. Standard echocardiographic and tissue Doppler imaging parameters were obtained. LA phasic volumes were assessed by 3D-echocardiography. From the 3D-echocardiography derived values, LA active, passive, and total emptying fraction (EF) were calculated. RESULTS: All left ventricular ejection fractions (LVEF) obtained by 2D and 3D-echocardiography were normal (≥50%). While LA diameters (33.36 ± 4.23 vs. 30.57 ± 5.43) and E/e' septal annulus ratios (10.82 ± 1.79 vs. 9.27 ± 1.81) were significantly higher, A-wave (70.80 ± 5.81 vs. 74.51 ± 5.41) and e'septal annular velocities (6.48 ± 1.58 vs. 9.03 ± 1.63) were significantly lower in the sarcoidosis group as compared with control group, respectively. While 3D-echocardiography derived LA-minimum volume indices (LAVImin) (13.89 ± 2.75 vs. 12.23 ± 1.73) were significantly higher, 3D-echocardiography derived LA active EFs (AAEF) (30.78 ± 3.52 vs. 38.52 ± 4.75) and LA total EFs (TAEF) (47.71 ± 7.47 vs. 53.32 ± 5.81) were found to be significantly lower in the sarcoidosis group as compared with control group, respectively. CONCLUSION: LAVImin, AAEF and TAEF calculated based on LA phasic volumes obtained by 3D-echocardiography may be promising indicators of subclinical cardiac involvement in asymptomatic patients with sarcoidosis.
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Solmaz et al. (2022) conducted a cross-sectional in sarcoidosis (n=84). 3D-echocardiography vs. Healthy volunteers was evaluated on Left atrial active emptying fraction (AAEF). Asymptomatic patients with sarcoidosis had significantly lower 3D-echocardiography derived left atrial active emptying fractions (30.78 vs 38.52) compared to healthy controls.
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