Key result
Large-scale sequencing of human cardiac cDNA libraries generated 84,904 expressed sequence tags, identifying 48 genes potentially overexpressed in cardiac hypertrophy.
Population
13 independent human cardiovascular system-based cDNA libraries
Design
Preclinical
Authors
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Supplies a foundational gene catalog for hypertrophy; leaves open functional validation and clinical translation.
The study provides a large-scale compilation of cardiovascular gene expression information, serving as a foundational genome-based resource for molecular cardiovascular medicine.
Hwang et al. (1997) studied Cardiovascular system. Large-scale partial sequencing of cDNA libraries was evaluated on Generation and classification of expressed sequence tags (ESTs). Large-scale sequencing of human cardiac cDNA libraries generated 84,904 expressed sequence tags, identifying 48 genes potentially overexpressed in cardiac hypertrophy.
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