Effects of Obstructive Sleep Apnea and Obesity on Cardiac Remodeling: The Wisconsin Sleep Cohort Study
Key result
Higher OSA severity linked to lower LVEF and ~6-fold greater odds of TAPSE ≤ 15 mm.
- OR 6.3
- 95% CI 1.3-30.5
- P=0.02
- n=601
Why the study?
Does obstructive sleep apnea lead to adverse cardiac remodeling and reduced ventricular function over long-term follow-up?
Population
601 participants from the general population, mean age 47 (SD 8) years, 47% female.
Comparison
Obstructive sleep apnea assessed by… vs Participants with lower or no OSA
Design
Cohort
Follow-up
mean 18.0 (SD 3.7) years
Authors
Discussion
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Member takes
Implication
OSA severity linked to future biventricular dysfunction; extends observational data but leaves causal effects open for RCTs.
Study Design
Type
Cohort (n=601)
Structured PICO
Does obstructive sleep apnea lead to adverse cardiac remodeling and reduced ventricular function over long-term follow-up?
P
Population
601 participants from the general population, mean age 47 (SD 8) years, 47% female.
I
Intervention
Obstructive sleep apnea (OSA) assessed by apnea-hypopnea index (AHI) via overnight polysomnography
C
Comparator
Participants with lower or no OSA (observational comparison)
O
Outcome
Future echocardiographic measures of adverse cardiac remodeling (LV systolic and diastolic function and mass, left atrial volume and pressure, cardiac output, systemic vascular resistance, and RV systolic function, size, and hemodynamics) at mean 18.0 yearssurrogate
Main Result
Effect estimate: OR 6.3 (95% CI 1.3-30.5)
p-value: p=0.02
Long-term exposure to obstructive sleep apnea is independently associated with reduced left and right ventricular systolic function, highlighting the need for early detection and integrated treatment.
Limitations
- Confounded by obesity
Cite This Study
Korcarz et al. (2016) conducted a cohort in Obstructive sleep apnea (n=601). Obstructive sleep apnea was evaluated on Reduced LV ejection fraction and tricuspid annular plane systolic excursion (TAPSE) ≤ 15 mm (OR 6.3, 95% CI 1.3-30.5, p=0.02). Higher baseline obstructive sleep apnea severity was independently associated with lower future left ventricular ejection fraction and higher odds of TAPSE ≤ 15 mm (OR 6.3; 95% CI 1.3-30.5; P=0.02).