Key result
Matrix metalloproteinase inhibition with doxycycline or GM6001 reduced aortic calcium accumulation in rodent models of aortic calcification.
Why the study?
Does matrix metalloproteinase inhibition reduce aortic calcification in rodent models?
Population
Male Sprague-Dawley rats with aortic calcification induced by vitamin D3, in vivo models of localized aortic…
Comparison
Matrix metalloproteinase inhibitors vs Controls
Design
Preclinical
Authors
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MMP inhibition merits further preclinical testing in aortic calcification; leaves open translation to human disease.
Does matrix metalloproteinase inhibition reduce aortic calcification in rodent models?
Inhibition of matrix metalloproteinases with doxycycline or GM6001 attenuates aortic calcification in rodent models, highlighting a potential therapeutic target for arterial calcification.
Qin et al. (2006) studied Aortic calcification. Doxycycline and GM6001 vs. Controls was evaluated on Aortic calcium accumulation. Matrix metalloproteinase inhibition with doxycycline or GM6001 reduced aortic calcium accumulation in rodent models of aortic calcification.
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