Key result
Vascular calcification score was a strong predictor of all-cause (HR 1.9; 95% CI 1.4-2.6) and cardiovascular mortality (HR 2.6; 95% CI 1.5-4.4) in end-stage renal disease patients.
Why the study?
Do arterial calcifications and arterial stiffness predict cardiovascular and all-cause mortality in end-stage renal disease patients on hemodialysis?
Population
110 stable end-stage renal disease patients on hemodialysis
Design
Cohort
Follow-up
53+/-21 months (mean+/-SD)
Authors
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May aid prognostic stratification in ESRD hemodialysis; leaves open whether targeting calcification improves outcomes.
Cohort (n=110)
Do arterial calcifications and arterial stiffness predict cardiovascular and all-cause mortality in end-stage renal disease patients on hemodialysis?
Effect estimate: HR 1.9 (95% CI 1.4 to 2.6)
p-value: p=<0.001
The presence and extent of vascular calcifications, along with carotid incremental elastic modulus, are strong independent predictors of cardiovascular and all-cause mortality in hemodialysis patients.
Blacher et al. (2001) conducted a cohort in End-Stage Renal Disease (n=110). Vascular calcification score and carotid incremental elastic modulus was evaluated on All-cause mortality (per 1-unit increase in calcification score) (HR 1.9, 95% CI 1.4 to 2.6, p=<0.001). Vascular calcification score was a strong predictor of all-cause (HR 1.9; 95% CI 1.4-2.6) and cardiovascular mortality (HR 2.6; 95% CI 1.5-4.4) in end-stage renal disease patients.
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