Syncope and Risk of Sudden Death in Hypertrophic Cardiomyopathy
Why the study?
Does unexplained syncope increase the risk of sudden death in patients with hypertrophic cardiomyopathy?
Population
1511 consecutive patients with hypertrophic cardiomyopathy
Comparison
Unexplained or neurally mediated syncope vs Patients without syncope
Design
Cohort
Follow-up
5.6+/-5.2 years
Authors
Discussion
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Member takes
Implication
May refine sudden death risk stratification in HCM; leaves open need for prospective validation before guiding ICD decisions.
Structured PICO
Does unexplained syncope increase the risk of sudden death in patients with hypertrophic cardiomyopathy?
P
Population
1511 consecutive patients with hypertrophic cardiomyopathy
I
Intervention
Unexplained or neurally mediated syncope
C
Comparator
Patients without syncope
O
Outcome
Sudden deathhard clinical
Unexplained syncope occurring within 6 months of initial evaluation is a strong independent risk factor for sudden death in patients with hypertrophic cardiomyopathy.
Cite This Study
Spirito et al. (2009) studied this question.