January 1, 1968Circulation
Impaired Rate of Left Ventricular Filling in Idiopathic Hypertrophic Subaortic Stenosis and Valvular Aortic Stenosis
Why the study?
Does idiopathic hypertrophic subaortic stenosis or valvular aortic stenosis impair left ventricular filling compared to normal subjects?
Population
86 subjects total: 27 patients with idiopathic hypertrophic subaortic stenosis, 22 patients with valvular…
Comparison
Hemodynamic analysis of the fall in pressure of… vs Normal subjects and patients with mitral stenosis
Design
Cross-sectional
Authors
Discussion
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Implication
Reduced y-descent metrics support impaired LV filling in IHSS and AS; leaves open prognostic value and therapeutic targeting.
Structured PICO
Does idiopathic hypertrophic subaortic stenosis or valvular aortic stenosis impair left ventricular filling compared to normal subjects?
P
Population
86 subjects total: 27 patients with idiopathic hypertrophic subaortic stenosis (IHSS), 22 patients with valvular aortic stenosis, 24 patients with mitral stenosis, and 13 normal subjects.
I
Intervention
Hemodynamic analysis of the fall in pressure (y descent) of the left atrial v wave following the opening of the mitral valve
C
Comparator
Normal subjects and patients with mitral stenosis
O
Outcome
y descent in 0.1 sec, mean rate of the y descent, and maximum rate of decline of the left atrial v wavesurrogate
Hemodynamic analysis demonstrates that left ventricular filling is impaired in idiopathic hypertrophic subaortic stenosis and valvular aortic stenosis, likely due to reduced left ventricular compliance.
Cite This Study
Stewart et al. (1968) studied this question.