Key result
Three-dimensional reconstruction of myosin filaments revealed that MyBP-C knockout disrupts some myosin head interactions, suggesting MyBP-C is important for normal relaxation of the filament.
Population
Myosin filaments from wild-type mouse cardiac muscle and from a MyBP-C knockout model for hypertrophic…
Comparison
Electron microscopy and image analysis for… vs Wild-type mouse cardiac muscle vs. MyBP-C…
Design
Preclinical
Authors
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Animal data link MyBP-C to myosin relaxation; extends filament structure knowledge but leaves open human translation.
This study provides 3D structural insights into vertebrate cardiac myosin filaments, demonstrating that MyBP-C is crucial for maintaining myosin head interactions and normal filament relaxation.
Zoghbi et al. (2008) studied Hypertrophic cardiomyopathy (HCM). MyBP-C knockout vs. Wild-type was evaluated on Three-dimensional structure of myosin filaments. Three-dimensional reconstruction of myosin filaments revealed that MyBP-C knockout disrupts some myosin head interactions, suggesting MyBP-C is important for normal relaxation of the filament.
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