November 1, 1964Circulation
Idiopathic Hypertrophic Subaortic Stenosis: II. Operative Treatment and the Results of Pre- and Postoperative Hemodynamic Evaluations
Key result
Operative treatment for idiopathic hypertrophic subaortic stenosis eliminated intraventricular pressure gradients in 6 of 7 followed patients and provided striking symptomatic improvement.
Why the study?
Does operative treatment (ventriculomyotomy with or without septal resection) improve symptoms and reduce intraventricular pressure gradients in patients with Idiopathic Hypertrophic Subaortic Stenosis?
Population
10 symptomatic patients with Idiopathic Hypertrophic Subaortic Stenosis undergoing operative treatment, ages…
Design
Case_series
Follow-up
7 to 51 months
Authors
Discussion
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Member takes
Implication
May support surgery for refractory IHSS symptoms; hypothesis-generating and should not yet change practice.
Study Design
Type
Observational (n=10)
Structured PICO
Does operative treatment (ventriculomyotomy with or without septal resection) improve symptoms and reduce intraventricular pressure gradients in patients with Idiopathic Hypertrophic Subaortic Stenosis?
P
Population
10 symptomatic patients with Idiopathic Hypertrophic Subaortic Stenosis (IHSS) undergoing operative treatment, ages 10 to 54 years, 8 males and 2 females. All symptomatic, 8 in functional classes III and IV.
I
Intervention
Operative treatment to relieve obstruction (simple left ventriculomyotomy in 5 patients, ventriculomyotomy combined with resection of hypertrophied interventricular septum in 5 patients)
O
Outcome
Symptomatic improvement and postoperative intraventricular pressure gradientsurrogate
Operative treatment for Idiopathic Hypertrophic Subaortic Stenosis (ventriculomyotomy/myectomy) provides striking symptomatic improvement and abolishes the intraventricular pressure gradient in the majority of surviving patients, though with risks of heart block and arrhythmia.
Cite This Study
Morrow et al. (1964) conducted an observational in Idiopathic Hypertrophic Subaortic Stenosis (IHSS) (n=10). Operative treatment (left ventriculomyotomy with or without septal resection) was evaluated on Symptomatic improvement and postoperative intraventricular pressure gradient. Operative treatment for idiopathic hypertrophic subaortic stenosis eliminated intraventricular pressure gradients in 6 of 7 followed patients and provided striking symptomatic improvement.