What is the clinical evidence from this study?

Study design: Review. Population: Cardiovascular disease. Intervention: Ultrasound contrast agents.

What question did this study set out to answer?

To provide a comprehensive assessment of ultrasound contrast agents repurposed from diagnostic imaging for therapeutic gene and drug delivery in cardiovascular medicine.

May 16, 2026Journal of the American College of Cardiology

Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine

View Full Paper

Ask AI

Bookmark

Key result

Ultrasound contrast agents show promise for non-invasive cardiovascular drug and gene delivery.

Design

Review

Authors

RBRaffi BekeredjianInterventional Cardiology PGPaul GrayburnCardiac Imaging RSRalph V. ShohetUniversity of Hawaiʻi at Mānoa

Discussion

Member takes

Implication

Ultrasound contrast agents show potential for non-invasive gene therapy and organ-specific drug delivery in cardiovascular medicine.

Key Points

To provide a comprehensive assessment of ultrasound contrast agents repurposed from diagnostic imaging for therapeutic gene and drug delivery in cardiovascular medicine.
Synthesized findings from published experimental and preclinical literature on ultrasound-mediated payload transport.
Evaluated acoustic delivery mechanisms, bioeffects, vector loading strategies, and organ-specific targeting feasibility.
Ultrasound-activated microbubbles facilitate site-specific extravasation and intracellular uptake of bioactive molecules and genetic constructs under localized acoustic fields.
Clinical translation requires overcoming technical hurdles including delivery efficiency, bioactivity preservation, and rigorous cardiovascular safety profiling.

Structured PICO

Intervention

Ultrasound contrast agents for gene or drug delivery

Ultrasound contrast agents show potential for non-invasive gene therapy and organ-specific drug delivery in cardiovascular medicine.

Cite This Study

Bekeredjian et al. (2005) conducted a review in Cardiovascular disease. Ultrasound contrast agents was evaluated. Ultrasound contrast agents show potential for non-invasive gene therapy and organ-specific drug delivery in cardiovascular medicine.

synapsesocial.com/papers/6a08df46d434fcb6f266dd75 https://doi.org/10.1016/j.jacc.2004.08.067

View Full Paper

Ask AI

Bookmark

Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider