Key result
Hydrogen sulfide and sulfur dioxide protect against CVD primarily via protein S-sulfhydration and S-sulfenylation.
Why the study?
The exact mechanisms underlying the actions of endogenous sulfur-containing gas signaling molecules H2S and SO2 in the cardiovascular system have remained elusive.
Proteins undergoing S-sulfhydration and S-sulfenylation by endogenous gas signaling molecules H2S and SO2 may serve as promising targets for therapeutic intervention in cardiovascular diseases.
Hydrogen sulfide (H 2 S) and sulfur dioxide (SO 2 ), recognized as endogenous sulfur-containing gas signaling molecules, were the third and fourth molecules to be identified subsequent to nitric oxide and carbon monoxide (CO), and exerted diverse biological effects on the cardiovascular system. However, the exact mechanisms underlying the actions of H 2 S and SO 2 have remained elusive until now. Recently, novel post-translational modifications known as S-sulfhydration and S-sulfenylation, induced by H 2 S and SO 2 respectively, have been proposed. These modifications involve the chemical alteration of specific cysteine residues in target proteins through S-sulfhydration and S-sulfenylation, respectively. H 2 S induced S-sulfhydrylation can have a significant impact on various cellular processes such as cell survival, apoptosis, cell proliferation, metabolism, mitochondrial function, endoplasmic reticulum stress, vasodilation, anti-inflammatory response and oxidative stress in the cardiovascular system. Alternatively, S-sulfenylation caused by SO 2 serves primarily to maintain vascular homeostasis. Additional research is warranted to explore the physiological function of proteins with specific cysteine sites, despite the considerable advancements in comprehending the role of H 2 S-induced S-sulfhydration and SO 2 -induced S-sulfenylation in the cardiovascular system. The primary objective of this review is to present a comprehensive examination of the function and potential mechanism of S-sulfhydration and S-sulfenylation in the cardiovascular system. Proteins that undergo S-sulfhydration and S-sulfenylation may serve as promising targets for therapeutic intervention and drug development in the cardiovascular system. This could potentially expedite the future development and utilization of drugs related to H 2 S and SO 2 .
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Song et al. (2023) conducted a review in Cardiovascular disease. Hydrogen sulfide (H2S) and sulfur dioxide (SO2) was evaluated. Hydrogen sulfide and sulfur dioxide regulate cardiovascular homeostasis and protect against cardiovascular diseases primarily through S-sulfhydration and S-sulfenylation of specific target proteins.
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