Key result
Impaired peripheral skeletal muscle metabolism and morphology strongly limit exercise capacity in PAH.
Why the study?
Exercise intolerance strongly impacts quality of life in pulmonary arterial hypertension, and the complex central, peripheral, and cerebrovascular mechanisms limiting exercise remain incompletely understood.
Population
Patients with pulmonary arterial hypertension
Design
Review
Authors
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Peripheral abnormalities may limit exercise capacity in PAH more than recognized; hypothesis-generating for muscle-targeted therapies.
This review highlights that peripheral and cerebrovascular abnormalities are key determinants of exercise intolerance in PAH, suggesting new targets for therapeutic intervention beyond central cardiopulmonary improvements.
Malenfant et al. (2021) conducted a review in Pulmonary arterial hypertension (PAH). Peripheral abnormalities, including impaired skeletal muscle morphology and metabolism, play a greater role in limiting exercise capacity in patients with PAH than previously thought.
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