Key result
HCM with preserved EF shows impaired LV global longitudinal strain compared to healthy controls.
Why the study?
To assess left ventricular function in hypertrophic cardiomyopathy patients with preserved LVEF using CMR-FT strain patterns and explore their relationships with cardiac biomarkers including cTnT and NT-proBNP.
Do left ventricular strain patterns assessed by CMR-FT correlate with cardiac biomarkers in HCM patients with preserved LVEF?
Population
64 HCM patients with preserved LVEF and 33 healthy people
Comparison
HCM patients with preserved LVEF vs healthy people
Design
Case-control study
Authors
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Impaired GLS signals subclinical dysfunction in HCM with preserved EF; leaves open whether CMR-FT strain refines biomarker-based risk assessment.
Case-Control (n=97)
No
Do left ventricular strain patterns assessed by CMR-FT correlate with cardiac biomarkers in HCM patients with preserved LVEF?
Absolute Event Rate: -9.44% vs -14.67%
p-value: p=<0.001
LV strain patterns assessed by CMR-FT can detect subclinical cardiac dysfunction in HCM patients with preserved LVEF and correlate with elevated NT-proBNP and cTnT.
Zhang et al. (2022) conducted a case-control in Hypertrophic cardiomyopathy with preserved left ventricular ejection fraction (n=97). Cardiac magnetic resonance feature tracking (CMR-FT) vs. Healthy controls was evaluated on Global longitudinal strain (GLS) (p=<0.001). In patients with hypertrophic cardiomyopathy and preserved ejection fraction, left ventricular global longitudinal strain was significantly impaired compared to healthy controls (-9.44% vs -14.67%).
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