What is the clinical evidence from this study?

Study design: Observational. Population: Cardiomyopathies (n=4267). Intervention: Dilated cardiomyopathy (DCM) vs. Hypertrophic cardiomyopathy (HCM). Primary outcome: 1-year mortality (p=<0.0001).

What question did this study set out to answer?

Determine the nationwide epidemiological distribution, clinical characteristics, and one-year outcomes across various cardiomyopathy subtypes.

January 1, 2002Circulation JournalOpen Access

Epidemiologic and Clinical Characteristics of Cardiomyopathies in Japan. Results From Nationwide Surveys.

Q: What are the key findings of this study?

In a nationwide survey in Japan, dilated cardiomyopathy was associated with a significantly higher 1-year mortality rate (5.6%) compared to hypertrophic cardiomyopathy (2.8%).

Q: What question did this study set out to answer?

Determine the nationwide epidemiological distribution, clinical characteristics, and one-year outcomes across various cardiomyopathy subtypes.

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Key result

In a nationwide survey in Japan, dilated cardiomyopathy was associated with a significantly higher 1-year mortality rate (5.6%) compared to hypertrophic cardiomyopathy (2.8%).

Population

Japanese patients with cardiomyopathies including idiopathic dilated cardiomyopathy, hypertrophic…

Design

Cohort

Follow-up

1 year

Authors

AMAkira MatsumoriKanazawa University YFYutaka FurukawaInterventional Cardiology KHKoji HasegawaKanazawa University

Discussion

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Implication

May inform DCM-specific monitoring for HF and arrhythmias; leaves open generalizability beyond Japan and causal factors.

Key Points

Determine the nationwide epidemiological distribution, clinical characteristics, and one-year outcomes across various cardiomyopathy subtypes.
Conducted nationwide clinico-epidemiological surveys covering dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), restrictive cardiomyopathy, and related disorders in Japan.
Administered a one-year follow-up survey on patients with DCM and HCM to assess mortality rates, causes of death, and pharmacological interventions.
Total estimated cases reached 21,900 for HCM and 17,700 for DCM, with both demonstrating substantial male predominance (male-to-female ratios of 2.3 and 2.6, respectively).
One-year mortality was 5.6% for DCM, primarily caused by congestive heart failure, compared to 2.8% for HCM, primarily caused by arrhythmias.
Pharmacotherapy for congestive heart failure complicating DCM frequently involved angiotensin-converting enzyme inhibitors (64.6%) and beta-adrenergic blockers (40.9%).

Study Design

Type

Observational (n=4,267)

Multicenter

Yes

Structured PICO

Population

Japanese patients with cardiomyopathies including idiopathic dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), restrictive cardiomyopathy (RCM), arrhythmogenic right ventricular dysplasia (ARVD), mitochondrial disease, Fabry's disease of the heart, and prolonged Q-T interval syndrome.

Outcome

Prevalence, 1-year mortality, and causes of deathhard clinical

Main Result

Absolute Event Rate: 5.6% vs 2.8%

p-value: p=<0.0001

Nationwide surveys in Japan reveal that DCM has a higher 1-year mortality than HCM, with congestive heart failure and arrhythmias being the respective leading causes of death.

Limitations

Survey was limited to individuals who visited hospitals, potentially missing asymptomatic subjects and underestimating true prevalence.
Did not analyze the long-term survival of the participants.
Hospital-based sampling may have biased the prevalence measured in men versus women.

Cite This Study

Matsumori et al. (2002) conducted an observational in Cardiomyopathies (n=4,267). Dilated cardiomyopathy (DCM) vs. Hypertrophic cardiomyopathy (HCM) was evaluated on 1-year mortality (p=<0.0001). In a nationwide survey in Japan, dilated cardiomyopathy was associated with a significantly higher 1-year mortality rate (5.6%) compared to hypertrophic cardiomyopathy (2.8%).

synapsesocial.com/papers/6a090815ea37c9c7dbe46b60 https://doi.org/10.1253/circj.66.323

Topics

Cardiomyopathy

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Epidemiologic and Clinical Characteristics of Cardiomyopathies in Japan. Results From Nationwide Surveys.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Epidemiologic and Clinical Characteristics of Cardiomyopathies in Japan. Results From Nationwide Surveys.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

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