Why the study?
Stress cardiomyopathy (takotsubo cardiomyopathy) is a rare condition subject to controversy and a lack of data regarding its pathogenic pathways.
This systematic review outlines the pathogenic pathways, pathology features, and diagnostic strategies for stress cardiomyopathy.
Informs updated diagnostic strategies for stress cardiomyopathy; extends synthesis of catecholamine-mediated pathogenic pathways.
In this article we describe a rare clinical condition of stress cardiomyopathy (takotsubo cardiomyopathy) for which we, despite controversy and lack of data, identified the main pathogenic pathways (including the direct toxic effect of catecholamines on the myocardium, catecholamine-mediated myocardial stunning, and microcirculation disorders). After the systematic review, we identified the distinct pathology features of this condition and new diagnostic strategies.
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Yashin et al. (2023) studied this question.
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