Key result
Takotsubo syndrome is linked to mortality and morbidity comparable to AMI, driven by non-cardiovascular causes.
Why the study?
Although Takotsubo syndrome shows rates of morbidity and mortality comparable to acute myocardial infarction, there are no robust data indicating the modality and timing of outpatient follow-up.
Takotsubo syndrome is not a benign condition, as it carries short- and long-term morbidity and mortality rates comparable to acute myocardial infarction, warranting comprehensive outpatient follow-up.
Supports extended follow-up after Takotsubo syndrome; leaves open targeted trials for non-cardiovascular mortality reduction.
Takotsubo syndrome (TTS) is an intriguing clinical entity, characterized by usually transient and reversible abnormalities of the left ventricular systolic function, mimicking the myocardial infarction with non-obstructive coronary arteries. TTS was initially regarded as a benign condition, however recent studies have unveiled adverse outcomes in the short- and long-term, with rates of morbidity and mortality comparable to those experienced after an acute myocardial infarction. Given the usual transient nature of TTS, this is an unexpected finding. Moreover, long-term mortality seems to be mainly driven by non-cardiovascular causes. The uncertain long-term prognosis of TTS warrants a comprehensive outpatient follow-up after the acute event, although there are currently no robust data indicating its modality and timing. The aim of the present review is to summarize recent available evidence regarding long-term prognosis in TTS. Moreover methods, timing and findings of the long-term management of TTS will be discussed.
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Sclafani et al. (2021) conducted a review in Takotsubo syndrome. Long-term management was evaluated. Takotsubo syndrome is associated with adverse short- and long-term morbidity and mortality rates comparable to acute myocardial infarction, mainly driven by non-cardiovascular causes.
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