Key result
Cardiogenic shock review highlights how hemodynamics, inflammation, and proteomics drive disease severity and prognosis.
Why the study?
Understanding the complex pathophysiology of cardiogenic shock, including macro- and micro-hemodynamics, inflammation, and proteomic features, is important to treat it optimally.
This review provides a comprehensive overview of the pathophysiology of cardiogenic shock, emphasizing the importance of understanding these mechanisms for optimal treatment.
May inform integrated macro-micro monitoring in cardiogenic shock; leaves open targeted therapies pending prospective trials.
PURPOSE OF REVIEW: We describe the pathophysiology of cardiogenic shock (CS), from the main pathways to the inflammatory mechanisms and the proteomic features. RECENT FINDINGS: Although the classical pathophysiological pathways underlying CS, namely reduced organ perfusion due to inadequate cardiac output and peripheral vasoconstriction, have been well-established for a long time, the role of macro-and micro-hemodynamics in the magnitude of the disease and its prognosis has been investigated extensively only over the last few years. Moreover, to complete the complex picture of CS pathophysiology, the study of cytokine cascade, inflammation, and proteomic analysis has been addressed recently. SUMMARY: Understanding the pathophysiology of CS is important to treat it optimally.
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Bertini et al. (2021) conducted a review in Cardiogenic shock. A review of cardiogenic shock pathophysiology highlights the critical roles of macro- and micro-hemodynamics, cytokine cascades, inflammation, and proteomic features in disease magnitude and prognosis.
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