Key result
Colchicine reverses atrial fibrosis in a rat AF model by modulating IL-17 and renin pathways.
Why the study?
Although colchicine can treat AF and reverse atrial fibrosis in rats, its potential therapeutic mechanisms against AF remained to be elucidated.
Does colchicine alter gene expression pathways in a rat model of atrial fibrillation?
Population
Rat model of AF
Design
Comparative transcriptome analysis
Authors
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Hypothesis-generating for colchicine in rat AF fibrosis; leaves open translation of IL-17/renin pathways to humans.
Does colchicine alter gene expression pathways in a rat model of atrial fibrillation?
Colchicine may treat atrial fibrillation and reverse atrial fibrosis through modulation of the IL-17 and renin secretion pathways.
Yue et al. (2019) studied Atrial fibrillation. Colchicine was evaluated on Differentially expressed genes and pathways. Colchicine treatment in a rat model of atrial fibrillation reversed atrial fibrosis and modulated the IL-17 signaling and renin secretion pathways.
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