Key result
Continuous wave Doppler ultrasound accurately measured pressure differences across bioprosthetic valves in vitro, correlating strongly with direct pressure measurements (r = 0.98).
Why the study?
Does continuous wave Doppler ultrasound accurately measure pressure differences across bioprosthetic valves compared to direct measurement in an in vitro pulsatile flow model?
Does continuous wave Doppler ultrasound accurately measure pressure differences across bioprosthetic valves compared to direct measurement in an in vitro pulsatile flow model?
Effect estimate: r = 0.98
Continuous wave Doppler ultrasound can accurately measure pressure differences across bioprosthetic valves in vitro.
Validates Doppler for in vitro valve gradients; leaves open clinical translation pending in vivo confirmation.
Continuous wave Doppler ultrasound was used in vitro to assess the pressure differences across four different cardiac bioprosthetic valves in a pulsatile flow test apparatus. Valves were tested under four different flow conditions. Pressure differences were calculated from the maximum flow velocity measured by Doppler ultrasound and correlated well with the pressure differences measured directly in the flow model (r = 0.98). Thus Doppler ultrasound can accurately measure pressure differences across bioprosthetic valves in vitro.
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Simpson et al. (1986) studied Cardiac bioprosthetic valves (in vitro) (n=4). Continuous wave Doppler ultrasound vs. Direct pressure measurement was evaluated on Correlation of pressure differences calculated from maximum flow velocity by Doppler ultrasound with direct pressure measurements (r = 0.98). Continuous wave Doppler ultrasound accurately measured pressure differences across bioprosthetic valves in vitro, correlating strongly with direct pressure measurements (r = 0.98).
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