Key result
Novel multi-biomarker panels alongside troponin and CK may improve early AMI diagnosis and risk stratification.
Why the study?
Older serum markers lack cardiac specificity and delay diagnosis, whereas novel biomarkers and a multi-biomarker approach may enhance diagnostic accuracy and early risk stratification in acute myocardial infarction.
Do novel biomarkers and a multi-biomarker approach improve the diagnostic accuracy and early risk stratification of acute myocardial infarction?
Do novel biomarkers and a multi-biomarker approach improve the diagnostic accuracy and early risk stratification of acute myocardial infarction?
Cardiac troponin and creatine kinase remain the most sensitive and specific markers for AMI, while novel multi-biomarker approaches hold promise for enhancing early diagnosis and risk stratification.
Myocardial infarction is a leading cause of death worldwide, and serum cardiac markers play an important role in diagnosing AMI (acute myocardial infarction). It is no longer recommended to use serum markers such as aspartate transaminase, lactate dehydrogenase, and lactate dehydrogenase subforms because they lack cardiac specicity and their delayed elevation prevents early diagnosis. The most sensitive and specic markers of myocardial damage appear to be cardiac troponin and creatine kinase. Recent studies have revealed several novel biomarkers and a multi biomarker approach can potentially enhance the diagnostic accuracy and provide more information for the early risk stratication of AMI. This review focuses on a variety of promising biomarkers which provide diagnostic and prognostic information.
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Varghese et al. (2022) conducted a review in Acute myocardial infarction. Biomarkers was evaluated. Novel multi-biomarker approaches, alongside cardiac troponin and creatine kinase, can potentially enhance diagnostic accuracy and early risk stratification of acute myocardial infarction.
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