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July 31, 2013International Journal of Bioassays

Clinical significance and effectiveness of various serum biomarkers in diagnosis of myocardial infarction

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Key result

Combining myoglobin with standard cardiac troponins may optimize early and definitive MI diagnosis.

Why the study?

What is the clinical significance and effectiveness of various serum biomarkers in the diagnosis of myocardial infarction?

Population

Patients with suspected acute myocardial infarction

Design

Review

Authors

HKHarpreet KaurAllegheny Health NetworkSGShalini GuptaMaharishi Markandeshwar University, MullanaMVMinni Verma

Discussion

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Implication

Troponins remain MI diagnostic standard; dual myoglobin approach leaves open need for prospective validation.

Structured PICO

What is the clinical significance and effectiveness of various serum biomarkers in the diagnosis of myocardial infarction?

P
Population
Patients with suspected acute myocardial infarction
E
Exposure
Serum biomarkers (cardiac troponins, myoglobin, heart type fatty acid binding protein, glycogen phosphorylase isoenzyme BB, ischaemia modified albumin)
O
Outcome
Diagnosis of acute myocardial infarctionsurrogate

This review highlights the ongoing evolution of MI biomarkers, emphasizing the gold standard role of troponins and the potential utility of early markers like myoglobin and emerging novel biomarkers.

Cite This Study

Kaur et al. (2013) conducted a review in Myocardial infarction. Serum biomarkers was evaluated. Cardiac troponins remain the gold standard for diagnosing myocardial infarction, though a dual-biomarker approach using myoglobin and troponins is proposed for optimal early and definitive diagnosis.

synapsesocial.com/papers/6aa2f9b4a585d718dda89a05https://doi.org/10.21746/ijbio.2013.08.003
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Also Consider

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  1. 1Acute Myocardial Infarction and Coronary Reperfusion: Serum Cardiac Markers for the 1990s1992 · 88 citations
  2. 2T-Cell–Mediated Lysis of Endothelial Cells in Acute Coronary Syndromes2002 · 360 citations
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  5. 5Role of reactive oxygen species on the formation of the novel diagnostic marker ischaemia modified albumin: Table 12005 · 225 citations