Key result
High troponin I is linked to a ~18% greater likelihood of significant CAD in NSTE-ACS.
Why the study?
Does the level of high-sensitivity troponin I elevation predict the presence of a flow-limiting lesion in patients with new-onset NSTE-ACS?
Cohort (n=561)
No
Does the level of high-sensitivity troponin I elevation predict the presence of a flow-limiting lesion in patients with new-onset NSTE-ACS?
This study aims to determine if the degree of high-sensitivity troponin I elevation predicts flow-limiting coronary lesions or LV systolic dysfunction in patients with new-onset NSTE-ACS.
Answers are grounded in this paper and cite their sources.
May aid risk stratification for significant CAD in NSTE-ACS; leaves open whether troponin levels predict flow-limiting lesions prospectively.
In acute coronary syndrome, elevated troponins are associated with worse clinical outcomes. We examined the relationship between the level of troponin elevation and the presence of a flow-limiting lesion for patients with no history of coronary disease admitted with NSTE-ACS. Methods: From January of 2010 until April of 2013, 561 patients received coronary angiography for new-onset NSTE-ACS. The Mann-Whitney Test, chi-square test, and Spearman correlation were used to examine relationships. Inferences were made at the 0.05 level of significance. The independent samples t test and the chi square test were used to identify predictors of LV systolic dysfunction-LVSD.
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Jabbar et al. (2017) conducted a cohort in Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) (n=561). High troponin I (>5.0 ng/ml) vs. Mild troponin I (<0.5 ng/ml) was evaluated on Presence of angiographically significant CAD (p=0.038). High troponin I levels were associated with a higher proportion of angiographically significant coronary artery disease compared to mild levels in patients with NSTE-ACS.
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