Key result
Diabetes alters costamere protein organization and increases living cardiomyocyte stiffness.
Why the study?
The structural organization of cardiomyocyte proteins is critical for contractile function, but the structural and elasticity changes induced by diabetes mellitus were unclear.
Diabetes mellitus induces structural disorganization and increased stiffness in living cardiomyocytes, providing a cellular basis for diabetic cardiomyopathy.
The structural organization of cardiomyocyte proteins is critical for their efficient functioning as a contractile unit in the heart. This work shows that diabetes mellitus induces significant changes in the spatial organization of costamere proteins, t tubules, and intercalated discs. We obtained the first elasticity map sections of living diabetic cardiomyocytes. The results show statistical differences in the map sections of diabetic and control cardiomyocytes, with diabetic cardiomyocytes being stiffer than normal ones.
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Romanelli et al. (2024) studied Diabetes mellitus. Diabetes mellitus vs. Control cardiomyocytes was evaluated on Spatial organization of costamere proteins and cardiomyocyte stiffness. Diabetes mellitus induces significant changes in the spatial organization of costamere proteins and increases the stiffness of living cardiomyocytes compared to normal controls.
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