March 1, 1987Circulation Research
Force, velocity, and power changes during normal and potentiated contractions of cat papillary muscle.
Key result
Postextrasystolic potentiation producing a 1.5 to twofold increase in peak developed force resulted in less than a 20% increase in extrapolated maximum velocity in cat papillary muscles.
Population
Cat papillary muscles
Comparison
Postextrasystolic potentiated contractions vs Normal contractions
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Animal data indicate Vmax is insensitive to inotropic modulation; leaves open optimal force-velocity indices for contractility research.
Structured PICO
P
Population
Cat papillary muscles
I
Intervention
Postextrasystolic potentiated contractions
C
Comparator
Normal contractions
O
Outcome
Instantaneous force-velocity relations (maximum velocity, isometric force, and maximum power)surrogate
In cat papillary muscles, maximum velocity remains relatively constant during a twitch, making extrapolated isometric force and maximum power more sensitive measures of changes in force-velocity curves.
Cite This Study
Chiu et al. (1987) studied Normal and postextrasystolic potentiated contractions in cat papillary muscle. Postextrasystolic potentiation vs. Normal contractions was evaluated on Force-velocity relations (maximum velocity, isometric force, maximum power). Postextrasystolic potentiation producing a 1.5 to twofold increase in peak developed force resulted in less than a 20% increase in extrapolated maximum velocity in cat papillary muscles.