Key result
Host immune responses drive viral myocarditis and DCM development through autoimmunity and innate immunity.
Host immune responses, including T cell, antibody, and innate immunity, play a critical role in the pathogenesis of viral myocarditis and its progression to dilated cardiomyopathy.
Supports immune-targeted strategies in viral myocarditis; leaves open need for RCTs before clinical adoption.
The pathogenesis of viral myocarditis includes both the direct damage mediated by viral infection and the indirect lesion resulted from host immune responses. Myocarditis can progress into dilated cardiomyopathy that is also associated with immunopathogenesis. T cell-mediated autoimmunity, antibody-mediated autoimmunity (autoantibodies), and innate immunity, working together, contribute to the development of myocarditis and dilated cardiomyopathy.
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Zhao et al. (2018) conducted a review in Viral Myocarditis and Dilated Cardiomyopathy. Host immune responses, including T cell-mediated autoimmunity, autoantibodies, and innate immunity, contribute to the development of viral myocarditis and dilated cardiomyopathy.
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