Key result
Atrial stretch, adrenergic stimulation, and endothelin are major triggers of natriuretic peptide release, with intracellular calcium homeostasis acting as a key regulatory element.
Design
Review
Authors
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Clarifies NP release triggers in HF; leaves open whether calcium modulation offers therapeutic targets.
Atrial stretch, adrenergic stimulation, and endothelin are major triggers of natriuretic peptide release, with intracellular calcium homeostasis playing a key regulatory role.
Thibault et al. (1999) conducted a review in Regulation of natriuretic peptide secretion. Atrial stretch, adrenergic stimulation, and endothelin are major triggers of natriuretic peptide release, with intracellular calcium homeostasis acting as a key regulatory element.
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