Key result
Combined inhibition of ETA/B and AT1 receptors almost completely blocked the ANP response to acute volume load (P<0.001), showing paracrine/autocrine factors mediate stretch-induced release.
Why the study?
Does combined inhibition of endothelin and angiotensin II receptors block volume load-induced cardiac hormone release in conscious rats?
Population
Conscious rats subjected to acute volume load
Comparison
Intravenous administration of BQ-123, bosentan… vs Vehicle-treated group
Design
Preclinical
Authors
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Should not change clinical volume management; leaves open human confirmation of paracrine ANP mediation.
Does combined inhibition of endothelin and angiotensin II receptors block volume load-induced cardiac hormone release in conscious rats?
p-value: p=<0.001
Endogenous paracrine and autocrine factors, particularly via ETA receptors, mediate mechanical stretch-induced cardiac ANP secretion in response to acute volume load.
Leskinen et al. (1997) studied Volume load-induced cardiac hormone release. Endothelin and angiotensin receptor antagonists (BQ-123, bosentan, losartan) vs. Vehicle was evaluated on Relative increase in plasma IR-ANP corresponding to a 3 mm Hg increase in right atrial pressure (p=<0.001). Combined inhibition of ETA/B and AT1 receptors almost completely blocked the ANP response to acute volume load (P<0.001), showing paracrine/autocrine factors mediate stretch-induced release.
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