Key result
CABG plus MV repair linked to ~16 ml/beat greater regurgitant volume reduction versus CABG alone in moderate MR.
Why the study?
Does combined mitral valve repair and CABG improve ventricular functions and effort capacities compared to CABG alone in patients with moderate ischemic mitral regurgitation?
Cohort (n=90)
No
Does combined mitral valve repair and CABG improve ventricular functions and effort capacities compared to CABG alone in patients with moderate ischemic mitral regurgitation?
Absolute Event Rate: -24.76% vs -8.7%
p-value: p=0.001
Adding mitral valve repair to CABG in patients with moderate ischemic mitral regurgitation significantly improves echocardiographic parameters of regurgitation at 1 year, though without significant differences in ejection fraction.
May reduce regurgitant volume at 1 year without EF change; leaves open effects on ventricular function or effort capacity in moderate ischemic MR.
OBJECTIVES: To investigate whether mitral valve repair (MVR) at the time of coronary artery bypass grafting (CABG) in patients with ischemic moderate mitral regurgitation (MR) and coronary artery disease could improve short- and mid-term postoperative outcomes. METHODS: Between March 2013 and December 2015, 90 patients with moderate ischemic MR underwent first-time CABG in Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey. Out of 90 patients, 44 (48.9%) underwent combined CABG+MVR. The remaining 46 (51.1%) underwent CABG alone. Ventricular functions and effort capacities of patients in both groups were evaluated echocardiographically and clinically in the preoperative period, and in the first postoperative year. RESULTS: Postoperative regurgitant volume changes according to preoperative values were -24.76±19 ml/beat in the combined CABG+MVR group, and -8.70±7.2 ml/beat in the CABG alone group (p=0.001). The change of vena contracta width was -3.40±0.2 mm in the combined CABG+MVR group whereas in the CABG alone -1.45±0.7 mm (p=0.019). The changes of left ventricular end-systolic volume index were -30.77±25.9 ml/m2 in the combined CABG+MVR group and -15.6±9.4 ml/m2 in the CABG alone group (p=0.096). Ejection fraction changes in the combined CABG+MVR group was +1.51±5.3% and in the CABG alone group was +1.15±4.3%. No statistically significant difference was found between both groups (p=0.604). Preoperative New York Heart Association class values in the combined CABG+MVR group was 2.18±0.45, and in the CABG alone group was 2.13±0.54. CONCLUSIONS: Moderate MR in patients undergoing CABG affects the outcome adversely and it does not reliably improve after CABG alone. Therefore, patients with ischemic moderate MR should undergo simultaneous MVR at the time of CABG.
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Toktaş et al. (2016) conducted a cohort in Ischemic moderate mitral regurgitation and coronary artery disease (n=90). Combined CABG and mitral valve repair vs. CABG alone was evaluated on Postoperative regurgitant volume change (ml/beat) (p=0.001). Combined CABG and mitral valve repair significantly reduced postoperative regurgitant volume compared to CABG alone (-24.76 vs -8.70 ml/beat; p=0.001) in patients with ischemic moderate MR.
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