Are specific echocardiographic diastolic function thresholds associated with increased long-term mortality risk in adult patients without significant left ventricular dysfunction or valvular disease?
Outcomes-based echocardiographic diastolic function thresholds for mortality risk differ from currently recommended cutoffs, with several parameters demonstrating a U-shaped risk relationship.
BACKGROUND: Currently recommended echocardiographic diastolic dysfunction thresholds are mostly derived from healthy adult populations rather than outcomes-based metrics. We identified thresholds of diastolic function parameters associated with increased long-term mortality risk. METHODS: Retrospective analysis of consecutive patients between 2011 and 2021. Repeat examinations, patients 0.88 m/s; E/A 1.65). CONCLUSIONS: Revised thresholds for maximal tricuspid regurgitation jet velocity, systolic pulmonary artery pressure and e' were found to be lower, and E/e' and deceleration time thresholds were higher, than cutoffs employed in current recommendations. U-shaped spline curves were observed for LAVI and most mitral inflow velocities, indicating increased mortality risk at low and high thresholds.
Loewenstein et al. (Thu,) studied this question.
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