Key result
Baseline relative wall thickness >0.42 (HR 1.88; 95% CI 1.28-2.59) and average E/e' >14 (HR 1.94; 95% CI 1.29-3.01) were significant risk factors for cardiac death or aortic valve replacement.
Why the study?
Do diastolic function indices (RWT >0.42 or E/e' >14) predict aortic valve replacement or cardiac death in asymptomatic patients with moderate mixed aortic valve disease?
Cohort (n=214)
No
Do diastolic function indices (RWT >0.42 or E/e' >14) predict aortic valve replacement or cardiac death in asymptomatic patients with moderate mixed aortic valve disease?
Hazard Ratio: 1.88 (95% CI 1.28–2.59)
p-value: p=0.001
In asymptomatic patients with moderate mixed aortic valve disease, elevated relative wall thickness and E/e' ratio identify a high-risk subset for cardiac death or AVR, with persistent risk even after valve replacement.
Identifies a high-risk subset in asymptomatic moderate mixed aortic valve disease; leaves open whether.
Aims: Determine the role of diastolic function indices in pre-operative and post-operative risk stratification in patients with moderate mixed aortic valve disease (MAVD). Methods and results: A retrospective study was conducted of asymptomatic patients with moderate MAVD (a combination of moderate aortic stenosis and moderate aortic regurgitation) and an ejection fraction of 50% or more who were followed up at Mayo Clinic from 1 January 2004, to 31 December 2013. A pre-requisite for inclusion in the study was assessment of diastolic function involving at least three of the following indices: tissue Doppler early diastolic velocity (e'), mitral inflow early velocity (E), tricuspid regurgitation velocity, and left atrial volume index. Primary endpoints were aortic valve replacement (AVR) or cardiac death while secondary endpoints were cardiovascular adverse events (CAEs) after AVR. We defined CAEs as stroke, heart failure hospitalization, severe left ventricular dysfunction, and cardiac death. There were 214 patients (age 61 ± 8 years, men 146 [68%]) followed for 6.1 ± 2.3 years during which 162 (76%) AVRs and 11 (5%) cardiac deaths occurred. The multivariable risk factors for cardiac death or AVR were relative wall thickness (RWT) > 0.42 [hazard ratio (HR), 1.88 [95% CI, 1.28-2.59]; P = 0.001] and average E/e' >14 (HR, 1.94 [95% CI, 1.29-3.01]; P = 0.02). Freedom from CAE after AVR was significantly lower in the patients with baseline RWT >0.42 or mean E/e' >14 than the other patients: 79% (95% CI 74-83%) vs. 94% (95% CI 89-98%) at 3 years (P = 0.03). Conclusion: The presence of RWT >0.42 or E/e' >14 identifies a high-risk patient subset whose risk for cardiovascular morbidities persists even after AVR.
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Egbe et al. (2017) conducted a cohort in moderate mixed aortic valve disease (n=214). Relative wall thickness >0.42 and average E/e' >14 vs. Relative wall thickness ≤0.42 and average E/e' ≤14 was evaluated on aortic valve replacement (AVR) or cardiac death (HR 1.88, 95% CI 1.28-2.59, p=0.001). Baseline relative wall thickness >0.42 (HR 1.88; 95% CI 1.28-2.59) and average E/e' >14 (HR 1.94; 95% CI 1.29-3.01) were significant risk factors for cardiac death or aortic valve replacement.
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