Key result
In patients with mixed aortic valve disease undergoing aortic valve replacement, worse postoperative LVEF (<50%) and LV-GLS (worse than -15%) were independently associated with higher mortality (P<0.001).
Why the study?
The implications of left ventricular remodeling and dysfunction before and after aortic valve replacement for mixed aortic valve disease are not well understood.
Does postoperative left ventricular systolic dysfunction (assessed by LVEF and LV-GLS) predict mortality in patients with mixed aortic valve disease undergoing aortic valve replacement?
Cohort (n=489)
Does postoperative left ventricular systolic dysfunction (assessed by LVEF and LV-GLS) predict mortality in patients with mixed aortic valve disease undergoing aortic valve replacement?
p-value: p=<.001
In patients with mixed aortic valve disease undergoing AVR, postoperative LV systolic dysfunction assessed by LVEF and LV-GLS is strongly associated with increased all-cause mortality.
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Postoperative LV-GLS and LVEF may refine post-AVR risk stratification in MAVD; leaves open whether they should guide decisions.
Saijo et al. (2023) conducted a cohort in Mixed aortic valve disease (n=489). Postoperative LVEF <50% and LV-GLS worse than -15% vs. Postoperative LVEF ≥50% and LV-GLS better than -15% was evaluated on All-cause mortality (p=<.001). In patients with mixed aortic valve disease undergoing aortic valve replacement, worse postoperative LVEF (<50%) and LV-GLS (worse than -15%) were independently associated with higher mortality (P<0.001).