Key result
E/e' fails to reliably assess left ventricular filling pressure changes in patients with preserved LVEF.
Why the study?
Does echocardiographic E/e′ accurately reflect invasive left ventricular filling pressure changes after exercise or pharmacological intervention?
Systematic Review
Does echocardiographic E/e′ accurately reflect invasive left ventricular filling pressure changes after exercise or pharmacological intervention?
There is insufficient evidence to support the use of E/e′ for reliably assessing LVFP changes in response to exercise or other interventions.
No takes yet. Share an insight, caveat, or question.
E/e' should not guide LVFP change assessment after interventions in preserved LVEF; challenges its dynamic use and leaves open need for validated alternatives.
Sharifov et al. (2017) conducted a systematic review in Left ventricular diastolic dysfunction. Echocardiographic tissue Doppler assessment (E/e') vs. Invasive left ventricular filling pressure measurement was evaluated on Reliability of E/e' to assess left ventricular filling pressure changes. Echocardiographic tissue Doppler assessment (E/e') was not useful for assessing left ventricular filling pressure changes in 7 of 9 studies (N=429) of patients with preserved LVEF.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: