Key result
E/e′ ratio correlates modestly with PAWP but performs poorly in identifying elevated LV filling pressures.
Why the study?
Does the E/e' ratio accurately estimate and track changes in pulmonary arterial wedge pressure in patients with unexplained dyspnea?
Observational (n=118)
Does the E/e' ratio accurately estimate and track changes in pulmonary arterial wedge pressure in patients with unexplained dyspnea?
Effect estimate: ROC area 0.65 (95% CI 0.50-0.79)
The E/e' ratio measured by echocardiography does not accurately estimate or track changes in pulmonary arterial wedge pressure in patients with unexplained dyspnea, challenging its utility as a noninvasive surrogate for left ventricular filling pressure.
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Caution against relying on E/e′ to estimate filling pressure in unexplained dyspnea; leaves open validation in prospective studies.
Santos et al. (2015) conducted an observational in Unexplained dyspnea (n=118). E/e′ ratio (transthoracic echocardiography) vs. Pulmonary arterial wedge pressure (right heart catheterization) was evaluated on Accuracy of E/e′ to identify elevated left ventricular filling pressure (ROC area 0.65, 95% CI 0.50-0.79). The E/e′ ratio correlated modestly with pulmonary arterial wedge pressure (r=0.36; P<0.001) and performed poorly in identifying elevated filling pressure (ROC area 0.65; 95% CI 0.50-0.79).
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