Key result
Hypertension was associated with significantly higher brachial-ankle pulse wave velocity and lower aortic distensibility compared to normotension, independent of left ventricular end-diastolic pressure.
Why the study?
Does hypertension or increased left ventricular end-diastolic pressure increase arterial stiffness?
Cross-Sectional (n=134)
No
Does hypertension or increased left ventricular end-diastolic pressure increase arterial stiffness?
Hypertension, rather than increased left ventricular end-diastolic pressure, appears to be the primary driver of increased arterial stiffness.
Hypertension may drive arterial stiffness independently of LVEDP; leaves open causal direction and need for longitudinal studies.
Objective: There have been few studies regarding the relationship between arterial stiffness and left ventricular end-diastolic pressure (LVEDP). In the current study, we evaluated the relationship between the LVEDP and arterial stiffness in patients with hypertension (HTN). Methods: Group I (n=34) included patients with a normal E/E’ (≤8) without HTN, group II (n=31) included patients with an elevated E/E’ (>8) without HTN, group III (n=20) included patients with a normal E/E’ (≤8) with HTN, and group IV (n=49) included patients with an elevated E/E’ (>8) with HTN. Aortic distensibility (AD) and the right brachial-ankle pulse wave velocity (baPWV) were measured. Results: The mean age was 46.0±11.3 years. The mean value of AD was significantly lower in the group III compared to the group I. The group IV showed significantly lower AD compared to the group II. The group III demonstrated higher baPWV compared to the group I (1422±182 cm/sec vs. 1186±178 cm/sec, p<0.01), and the group IV showed higher baPWV compared to the group II (1456±228 vs. 1259±238 cm/sec, p<0.01). However, AD and baPWV were not significantly different between the group I and II, and between the group III and IV. The E/E’ ratio showed a weak negative correlation with AD and a weak positive correlation with baPWV. Conclusion: Patients with hypertension showed a lower AD and a higher baPWV compared to those with normal blood pressure independent of the LVEDP. But the correlation between E/E’ ratio and arterial stiffness suggests that a high LVEDP might not significantly influence arterial stiffness.
No takes yet. Share an insight, caveat, or question.
Park et al. (2013) conducted a cross-sectional in Hypertension and elevated left ventricular end-diastolic pressure (n=134). Hypertension vs. Normotensive controls was evaluated on Brachial-ankle pulse wave velocity (baPWV) in patients with normal E/E' ratio (p=<0.01). Hypertension was associated with significantly higher brachial-ankle pulse wave velocity and lower aortic distensibility compared to normotension, independent of left ventricular end-diastolic pressure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: