March 13, 2014PLoS ONEOpen Access

Continuous Cardiac Troponin I Release in Fabry Disease

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Why the study?

Is persistent cardiac troponin I elevation associated with cardiac dysfunction (LGE on cMRI) in patients with Fabry disease?

Population

14 patients with Fabry disease (6 males, 8 females) regularly followed-up at a single center.

Design

Cohort

Authors

AFA. FeustelJohannes Gutenberg University Mainz AHAndreas HahnLeibniz University Hannover CSChristian SchneiderIllinois Mathematics and Science Academy

Discussion

Member takes

Implication

Persistent cTNI elevation was associated with LGE on cMRI in Fabry disease; hypothesis-generating for biomarker use and requires prospective validation.

Structured PICO

Is persistent cardiac troponin I elevation associated with cardiac dysfunction (LGE on cMRI) in patients with Fabry disease?

Population

14 patients with Fabry disease (6 males, 8 females) regularly followed-up at a single center.

Intervention

Measurement of cardiac troponin I (cTNI) at least twice per year.

Outcome

Frequency of cardiac troponin I (cTNI) elevation and its association with cardiac dysfunction assessed by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (cMRI).surrogate

Continuous cTNI elevation in Fabry disease is strongly associated with late gadolinium enhancement on cMRI, suggesting it is a useful biomarker for myocardial damage.

Limitations

Small cohort size

Cite This Study

Feustel et al. (2014) studied this question.

synapsesocial.com/papers/6a090d1e2142fc3a3073bdd1 https://doi.org/10.1371/journal.pone.0091757

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Implication

Persistent cTNI elevation was associated with LGE on cMRI in Fabry disease; hypothesis-generating for biomarker use and requires prospective validation.

Continuous Cardiac Troponin I Release in Fabry Disease

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Continuous Cardiac Troponin I Release in Fabry Disease

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider