Key result
Raised serum troponin T concentration at admission independently predicted inpatient mortality in acute ischaemic stroke patients (40% vs 13%; RR 3.2; 95% CI 1.7-5.8; P=0.0025).
Why the study?
Does raised serum troponin T concentration predict inpatient mortality in patients with acute ischaemic stroke?
Observational (n=181)
No
Does raised serum troponin T concentration predict inpatient mortality in patients with acute ischaemic stroke?
Effect estimate: RR 3.2 (95% CI 1.7-5.8)
Absolute Event Rate: 40% vs 13%
p-value: p=0.0025
Raised serum troponin T concentration at admission is a powerful independent predictor of inpatient mortality in patients with acute ischaemic stroke.
May aid risk stratification on admission in acute ischaemic stroke; leaves open whether targeted interventions improve survival.
OBJECTIVE: To assess whether a raised serum troponin T concentration would be an independent predictor of death in patients with an acute ischaemic stroke. DESIGN: Observational study. SETTING: Auckland Hospital, Auckland, New Zealand. SUBJECTS: All 181 patients with an acute ischaemic stroke admitted over nine months in 1997-8, from a total of 8057 patients admitted to the acute medical service. MAIN OUTCOME MEASURES: Blood samples for measuring troponin T concentration were collected 12-72 hours after admission; other variables previously associated with severity of stroke were also recorded and assessed as independent predictors of inpatient mortality. RESULTS: Troponin T concentration was raised (>0.1 microgram/l) in 17% (30) of patients admitted with an acute ischaemic stroke. Thirty one patients died in hospital (12/30 (40%) patients with a raised troponin T concentration v 19/151 (13%) patients with a normal concentration (relative risk 3.2 (95% confidence 1.7 to 5. 8; P=0.0025)). Of 17 possible predictors of death, assessed in a multivariate stepwise model, only a raised troponin T concentration (P=0.0002), age (P=0.0008), and an altered level of consciousness at presentation (P=0.0074) independently predicted an adverse outcome. CONCLUSIONS: Serum troponin T concentration at hospital admission is a powerful predictor of mortality in patients admitted with an acute ischaemic stroke.
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Paul A. James (2000) conducted an observational in Acute ischaemic stroke (n=181). Raised serum troponin T concentration (>0.1 microgram/l) vs. Normal troponin T concentration was evaluated on Inpatient mortality (RR 3.2, 95% CI 1.7-5.8, p=0.0025). Raised serum troponin T concentration at admission independently predicted inpatient mortality in acute ischaemic stroke patients (40% vs 13%; RR 3.2; 95% CI 1.7-5.8; P=0.0025).
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