Key result
Review outlines sex-specific computational models explaining male-female differences in blood pressure regulation.
Why the study?
Recent data on sex differences across physiological systems have the potential to reveal mechanisms in blood pressure control, requiring computational models to elucidate these complex interactions.
Computational modeling provides a valuable tool to elucidate the complex physiological mechanisms underlying sex differences in blood pressure regulation.
Sex differences in blood pressure and the prevalence of hypertension are found in humans and animal models. Moreover, there has been a recent explosion of data concerning sex differences in nitric oxide, the renin-angiotensin-aldosterone system, inflammation, and kidney function. These data have the potential to reveal the mechanisms underlying male-female differences in blood pressure control. To elucidate the interactions among the multitude of physiological processes involved, one may apply computational models. In this review, we describe published computational models that represent key players in blood pressure regulation, and highlight sex-specific models and their findings.
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Ahmed et al. (2019) conducted a review in Hypertension and blood pressure regulation. Computational modeling was evaluated. This review describes published computational models representing key players in blood pressure regulation and highlights sex-specific models to elucidate mechanisms underlying male-female differences.
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